Milk thistle contains silymarin and silybin, antioxidants that are known to help protect the liver from toxins, including the effects of alcohol. Not only has silymarin been found to increase glutathione, but it also may help to regenerate liver cells.

Alcohol may deplete your body of vitamin C, which is important for reducing alcohol-induced oxidative stress in your liver. Make sure you're getting adequate amounts of vitamin C, either through supplements or citrus fruits, before taking any alcoholic beverage.

Glutathione is a key element of the livers detoxifying process and also the precursor for glutathione peroxidase, a major free radical scavenging enzyme. Glutathione is critical for healthy immune system function.

Alcohol depletes essential B vitamins, which help to eliminate it from the body. NAC is thought to work even better when combined with thiamine, or vitamin B1.